Omega-3 Fatty Acid Accelerates Progression of ALS

Omega-3 Fatty Acid Accelerates Progression of ALS

Researchers in the UK set out to study the effect of Omega-3 polyunsaturated fatty acids (PUFAs) on ALS. While compounds like Eicosapentaenoic Acid (EPA) have been previously shown to have neuroprotective effects, the researchers found that in cases of mutant SOD1, the gene that has been linked with ALS, mice on a diet containing 300 mg/kg/day dose of EPA (blue line) had decreased survival rate compared to the same mice on the control diet (red line). Furthermore, the group also observed increased vacuolization and lipid-linked oxidation of microglia in the spinal cord. While the dosage is really high and the study is done in mice, the data provides new insight into potential new factors that relate to ALS progression.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061626

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6 thoughts on “Omega-3 Fatty Acid Accelerates Progression of ALS

  1. It’s weird that the researchers thought this would have a positive effect on neuron protection, and it ended up actually having a negative impact on lifespan. A very interesting finding to say the least.

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