From the Lab of Our Favorite Researcher (Dough Melton) : Discovery of Betatrophin–Potential for New Diabetes Treatment Replacing Insulin Injections

From the Lab of Our Favorite Researcher (Dough Melton) : Discovery of Betatrophin--Potential for New Diabetes Treatment Replacing Insulin Injections

A paperfrom Doug Melton’s group published in Cell (153, 4, 747-758) this month made a fascinating new discovery. Pancreatic B cells are responsible for the production of insulin in the body. Thus, regulating the proliferation of these cells is of great interest. The researchers used a mouse model of diabetes and using an antagonist blocked insulin receptors that surprisingly led to a higher proliferation of these cells. To determine what proteins were responsible for the proliferation, a microarray study was performed in which Betatrophin was found as a potential new hormone regulator. Expression of Betatrophin in mouse liver significantly increased B cell replication rates (red stained cells on the bottom row of the figure) causing higher levels of insulin (green bottom row) and improved glucose tolerance compared to control mice (top row). The study helps provide new methods for treatment of diabetes in the future and highlights the importance of basic research! It’s also Fancy!

Full Article Link:

http://www.cell.com/abstract/S0092-8674(13)00449-2

Advertisements

5 thoughts on “From the Lab of Our Favorite Researcher (Dough Melton) : Discovery of Betatrophin–Potential for New Diabetes Treatment Replacing Insulin Injections

  1. Betatrohpins look pretty promising. For some diabetics I think beta cells might be wiped out entirely, so I wonder if that has any effect on how this treatment would be utilized.

    1. I know that’s one of the things I wondered about. I think the paper focused more on type II diabetes. But I wonder if stem cells could be used as an initial source for the beta cells and then supplemented with betatrophin. We’ll have to watch the Melton lab closely!!

  2. Well he may not have a found a cure (YET!) but it would be appear that he is onto a major breakthrough. I’m glad that he is after being so invested in the research.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s