This is another “old” Ted Talk Video, but still one that shows how basic science using fluorescence can help surgeons identify tumors and identify organ specific cancers visually rather than solely depending on pathologists in the laboratory. I don’t think Roger Tsien set out to study Aequorea victoria and isolated Green Fluorescent Protein so that we could do better surgery one day. But as a result of his basic–nobel prize winning–research many cancer patients are able to benefit from improved surgical techniques. It’s Fancy! Hope you enjoy it!
The molecular cause of many cancers associated with blood remains unclear. However, using deep sequencing techniques, scientists at the Oregon Health & Science University were able to identify mutations in colony-stimulating factor 3 receptors (CSF3R) in 16 of 27 patients (59%) with chronic neutrophilic leukemia or chronic myeloid leukemia. These mutations caused alterations in kinase signaling pathways (JAK and TNK2). The discovery could serve as a new tool for diagnosing leukemia in patients.