Tag Archives: Mutation

Got Blue Eyes? Better thank that one person that lived 10,000 years ago

Got Blue Eyes?  Better thank that one person that lived 10,000 years ago

As a person whose favorite color is blue and lives in the town where wearing anything but blue in March is equivalent to asking for your friendships to end (Lexington KY), I thought I had to share this with you. Apparently, the mutation in OCA2 gene that resulted in blue eyes can be traced back to a single individual who lived around 10 centuries ago. But, the research also used mitochondrial DNA to determine inheritance patterns (it’s really hard to say anything conclusive with each generation that you go back when working with mtDNA). Still thought it was pretty Fancy. Go Blue!

http://www.sciencedaily.com/releases/2008/01/080130170343.htm

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Discovery of A New Leukemia Oncogene

Discovery of New Leukemia Gene

The molecular cause of many cancers associated with blood remains unclear. However, using deep sequencing techniques, scientists at the Oregon Health & Science University were able to identify mutations in colony-stimulating factor 3 receptors (CSF3R) in 16 of 27 patients (59%) with chronic neutrophilic leukemia or chronic myeloid leukemia. These mutations caused alterations in kinase signaling pathways (JAK and TNK2). The discovery could serve as a new tool for diagnosing leukemia in patients.

http://www.nejm.org/doi/full/10.1056/NEJMoa1214514

http://www.sciencedaily.com/releases/2013/05/130510102111.htm