Tag Archives: Oregon Health & Science University

Discovery of A New Leukemia Oncogene

Discovery of New Leukemia Gene

The molecular cause of many cancers associated with blood remains unclear. However, using deep sequencing techniques, scientists at the Oregon Health & Science University were able to identify mutations in colony-stimulating factor 3 receptors (CSF3R) in 16 of 27 patients (59%) with chronic neutrophilic leukemia or chronic myeloid leukemia. These mutations caused alterations in kinase signaling pathways (JAK and TNK2). The discovery could serve as a new tool for diagnosing leukemia in patients.

http://www.nejm.org/doi/full/10.1056/NEJMoa1214514

http://www.sciencedaily.com/releases/2013/05/130510102111.htm

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